![]() Studies were performed as part of a quality assurance project designed to compare oximeter performance and accuracy. The purpose of this study is to compare the performance of MouseOx® Plus and MouseSTAT®. One such product is PhysioSuite® with MouseSTAT® from Kent Scientific (KS) Since the introduction of the original MouseOx® in 2006, other pulse oximeters claiming to be effective for use on laboratory mice and rats have emerged. MouseOx® has been calibrated for murine blood, optimized for pulse rates as high a 900 BPM, and has been validated against co-oximetry as the gold standard measurement of SaO2 (Strohl et al., 2007). The Starr Life Sciences (SLS) MouseOx® Plus was designed specifically to be a research grade pulse oximeter optimized for use on mice and rats. In the applications mentioned above, accuracy and reliability of SpO2 measurements is vital in order to provide an objective measure of the animal’s condition at any given time. The plethysmogram (pulsatile waveform) generated by a pulse oximeter and output as an analog signal has been used to provide cardiac-based triggering for use in imaging applications (cardiac gating). With the use of specially designed cages and tether management pulse oximetry can be used to monitor SpO2 in conscious, freely moving small animals. SpO2 is an important, sometimes primary, reported parameter in areas of research including but not limited to: cardiopulmonary dysfunction, altitude effects, exercise/activity, toxicology, obesity, metabolic studies, etc. As a vital signs monitor, pulse oximetry ascertains one critical component of oxygen delivery in experimental subjects and can establish consistency before, during and after experimental procedures, as well as monitor dynamic changes occurring as a result of intent (imposed hypoxia) or circumstance, like induction or maintenance of anesthesia. When referring to subjects as small as laboratory mice and rats, loss of blood from blood samples can introduce additional hemodynamic and reflex variables to the model as well as compromise overall health.Ĭontinuous pulse oximetry, now a standard anesthesia/surgical monitor for humans, has been applied to laboratory animals, and is used in many research monitoring and applications. Also risk to the experimenter from needle stick, time, and cost of consumable items are reduced or eliminated. Pulse oximetry is noninvasive, and, compared to an arterial blood draw through needle puncture or indwelling catheter, reduces the risk of complications such as trauma, infection and discomfort to the patient or subject. A pulse oximeter continuously and noninvasively measures functional arterial blood oxygen saturation (SpO2). Pulse oximetry is the fifth vital sign in human health and has become useful in animal research for monitoring and for planning of cardiopulmonary studies in anesthetized and conscious models. Strohl, Professor of Medicine, Physiology and Biophysics Click here to download the PDF of this whitepaper 1. Jennifer Gamble, Registered Veterinary Technician David Nethery, Senior Research Associate, Kingman P. warming system, includes controller, warming pad (20.3 cm W x 25.Comparison of Starr Life Sciences’ MouseOx® Plus and Kent Scientifics’ MouseSTAT® Pulse Oximeters Addendum A to: Validation of the MouseOx® Arterial Oxygen Saturation Measurements (Strohl et al., 2007)Ĭase Western Reserve University, September 1, 2016 warming system, includes controller, warming pad (15.2 cm W x 20.3 cm L), 2 temperature probes, and 10 disposable, non-sterile sleeve protectors Rat Paw Pulse Oximeter Sensors – For all existing systems with serial #s that do not end in "-B" Rat Paw Pulse Oximeter Sensors – For all new systems, existing systems with serial # ending in "-B", and all MouseSTAT Jr.s Pulse Oximeter Whole Body Sensors, MRI-Compatible – For Mouse Pups 3 Days Old Pulse Oximeter Paw Sensors, MRI-Compatible – MRI Sensor for Rats Pulse Oximeter Paw Sensors, MRI-Compatible – MRI Sensor for Rat Pups Pulse Oximeter Paw Sensors, MRI-Compatible – MRI Sensor for Mice MouseSTAT® Pulse Oximeter Whole Body Sensors for Mouse Pups – For Mouse Pups 3 Days Old MouseSTAT® Pulse Oximeter Paw Sensors for Rat Pups – MouseSTAT Pulse Oximeter Paw Sensor for Rat Pups Mouse Paw Pulse Oximeter Sensors – For all existing systems with serial #s that do not end in "-B" Mouse Paw Pulse Oximeter Sensors – For all new systems, existing systems with serial #s ending in "-B", and all MouseSTAT Jr.s Large Animal Sensors – For all existing systems with serial #s that do not end in "-B" ![]() Large Animal Sensors – For all new systems, existing systems with serial #s ending in "-B", and all MouseSTAT Jr.s Analog Output Cable – Analog Output Cable
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